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It does not prevent transmission to others. Be continued for up to ten months. When acyclovir is used to prevent outbreaks of genital herpes, it is usually taken with or without food two to five times a day for five days, starting as soon as you feel the tingle of a cold sore appearing. When applying Acyclovir to avoid spreading the virus to other body parts and to other people. Acyclovir may reduce the severity and duration of a shingles attack if given soon after the onset of symptoms. Acyclovir is given to help prevent the infection from coming back. Acyclovir is an antiviral treatment for cold sores.